%0 Journal Article
%T Clinical trials in pulmonary sarcoidosis; what is needed, what is happening and what is next?
%A Veltkamp M
%J Curr Opin Pulm Med
%V 30
%N 5
%D 2024 Sep 1
%M 38963156
%F 2.868
%R 10.1097/MCP.0000000000001098
%X <B>OBJECTIVE: </B>There is a clinical unmet need to improve treatment for patients with pulmonary sarcoidosis. Both retrospective and prospective drug trials are hampered by the fact that patients with sarcoidosis are characterized by a heterogeneous presentation and disease course. In this review, an overview is given of different drug trials in pulmonary sarcoidosis with an emphasis on different primary endpoints and the problems related to them.<BR><B>RESULTS: </B>In recent years, using significant input from patients with sarcoidosis, different task-forces/studies tried to develop a core set of most important outcomes to measure in future studies on treatment of sarcoidosis. Furthermore, at present, three major clinical trials are being conducted on new drugs for treatment of pulmonary sarcoidosis.<BR><B>CONCLUSIONS: </B>Progress has been made to develop a core set of outcomes measures that can be used in making a combined primary endpoint in future drug trials in sarcoidosis.