%0 Journal Article
%T Heptaellipside A, a rare new 2,28-bidesmosidic lupane-type saponin from the leaves of Heptapleurum ellipticum.
%A Ngo TN
%A Nguyen TA
%A Huynh NT
%A Ly HD
%A Dang THN
%A Nguyen TKP
%A Huynh KY
%A Dang VS
%A Nguyen QH
%A Ngo QL
%A Do THT
%A Dung Hoang TK
%A Nguyen TP
%J Nat Prod Res
%V 0
%N 0
%D 2024 Jul 4
%M 38962963
%F 2.488
%R 10.1080/14786419.2024.2375311
%X For the first time, phytochemical constituents of the leaves of Heptapleurum ellipticum were investigated. One rare new 2,28-bidesmosidic lupane-type saponin, named heptaellipside A (1), along with four other lupane-type analogs (2-5) were purified by combining differently chromatographic methods. All of the separated compounds (1-5) were communicated for the first time from H. ellipticum. The structures of them were definitely illustrated following extensive and comprehensive UV/VIS, FTIR, HRMS/ESI, and NMR techniques. Further, all isolated compounds were evaluated for their α-glucosidase and α-amylase inhibition. As the results, compound 3 respectively exhibited stronger in both inhibitory activities against α-glucosidase and α-amylase (IC50 values of 15.53 and 26.93 μM), than the acarbose standard (IC50 values of 214.50 and 143.48 μM).