%0 Journal Article
%T A mitochondrial checkpoint to NF-κB signaling.
%A Guilbaud E
%A Galluzzi L
%J Cell Death Dis
%V 15
%N 7
%D 2024 Jul 3
%M 38961079
暂无%R 10.1038/s41419-024-06868-3
%X Mitochondrial dysfunction can elicit multiple inflammatory pathways, especially when apoptotic caspases are inhibited. Such an inflammatory program is negatively regulated by the autophagic disposal of permeabilized mitochondria. Recent data demonstrate that the ubiquitination of mitochondrial proteins is essential for NEMO-driven NF-kB activation downstream of mitochondrial permeabilization.