%0 Journal Article
%T Metastatic Pleomorphic Carcinoma of the Lung with Extensive Chromosomal Rearrangements: An Autopsy Case with a Literature Review.
%A Matsumoto F
%A Matsuzawa Adachi M
%A Yoshida K
%A Yamashita T
%A Shiihara J
%A Fukuchi T
%A Morikawa H
%A Hiruta M
%A Tanno K
%A Oyama-Manabe N
%A Oshiro H
%A Sugawara H
%J Intern Med
%V 0
%N 0
%D 2024 Jul 4
%M 38960695
%F 1.282
%R 10.2169/internalmedicine.3478-24
%X We herein report a 47-year-old man who presented with progressive paraparesis. Imaging revealed a right upper pulmonary nodule, massive bilateral adrenal metastases, thoracolumbar vertebral osteolysis, and subcutaneous nodules. A biopsy of the right buttock nodule revealed a poorly differentiated metastatic carcinoma with high programmed cell death-ligand 1 expression and extensive chromosomal rearrangements. The patient died 10 days after the initiation of pembrolizumab treatment. Autopsy findings confirmed pulmonary pleomorphic carcinoma with extensive metastases. Quantification of chromosomal rearrangements revealed a jump-up mutation from the normal karyotype, followed by a further incremental increase in the degree of deviation.