%0 Journal Article %T From whence it came: Mitochondrial mRNA leaves, a protein returns. %A Janssen KA %A Song A %J Cell Metab %V 36 %N 7 %D 2024 Jul 2 %M 38959859 %F 31.373 %R 10.1016/j.cmet.2024.06.002 %X Small peptides have previously been reported to be encoded in mitochondrial rRNA and translated by cytosolic ribosomes. In this issue of Cell Metabolism, Hu et al. use mass spectrometry to identify a cytosolically translated protein, encoded instead in mitochondrial mRNA, that is surprisingly targeted back into the mitochondrial matrix.