%0 Journal Article
%T Exploring the mechanism of Si-Miao-Yong-An decoction on heart failure based on molecular docking and network pharmacology.
%A Qiu H
%A Zhao SN
%A Han JL
%A Yu M
%A Wang RD
%A Fang JR
%A Luo YZ
%A Zhu LJ
%A Yao XS
%J J Asian Nat Prod Res
%V 0
%N 0
%D 2024 Jul 3
%M 38958647
%F 1.61
%R 10.1080/10286020.2024.2370409
%X The SwissTargetPrediction was employed to predict the potential drug targets of the active component of Si-Miao-Yong-An decoction (SMYAD). The therapeutic targets for HF were searched in the Genecard database, and Cytoscape3.9.1 software was used to construct the "drug-component-target-disease network" diagram. In addition, the String platform was used to construct Protein-Protein Interaction (PPI) network, and the DAVID database was used for GO and KEGG analysis. AutoDockTools-1.5.6 software was used for molecular docking verification. Network pharmacology studies have shown that AKT 1, ALB, and CASP 3 are the key targets of action of SMYAD against heart failure. The active compounds are quercetin and kaempferol.