%0 Journal Article
%T Sex disparities of the effect of the COVID-19 pandemic on mortality among patients living with tuberculosis in the United States.
%A Deng H
%A Liu Y
%A Lv F
%A Li X
%A Qi M
%A Bo Y
%A Qiu S
%A He X
%A Ji F
%A Zeng QL
%A Gao N
%J Front Public Health
%V 12
%N 0
%D 2024
%M 38957204
%F 6.461
%R 10.3389/fpubh.2024.1413604
%X <B>UNASSIGNED: </B>We aimed to determine the trend of TB-related deaths during the COVID-19 pandemic.<BR><B>UNASSIGNED: </B>TB-related mortality data of decedents aged ≥25 years from 2006 to 2021 were analyzed. Excess deaths were estimated by determining the difference between observed and projected mortality rates during the pandemic.<BR><B>UNASSIGNED: </B>A total of 18,628 TB-related deaths were documented from 2006 to 2021. TB-related age-standardized mortality rates (ASMRs) were 0.51 in 2020 and 0.52 in 2021, corresponding to an excess mortality of 10.22 and 9.19%, respectively. Female patients with TB demonstrated a higher relative increase in mortality (26.33 vs. 2.17% in 2020; 21.48 vs. 3.23% in 2021) when compared to male. Female aged 45-64 years old showed a surge in mortality, with an annual percent change (APC) of -2.2% pre-pandemic to 22.8% (95% CI: -1.7 to 68.7%) during the pandemic, corresponding to excess mortalities of 62.165 and 99.16% in 2020 and 2021, respectively; these excess mortality rates were higher than those observed in the overall female population ages 45-64 years in 2020 (17.53%) and 2021 (33.79%).<BR><B>UNASSIGNED: </B>The steady decline in TB-related mortality in the United States has been reversed by COVID-19. Female with TB were disproportionately affected by the pandemic.