%0 Journal Article
%T Association between parental decisions regarding abortion and severity of fetal heart disease.
%A Nakao M
%A Kuwabara M
%A Saito M
%A Horiuchi C
%A Morisaki H
%A Kishiki K
%A Hamamichi Y
%A Orui I
%A Ono R
%A Suzuki R
%A Izawa M
%A Maeda Y
%A Ohmori A
%A Uyeda T
%A Yazaki S
%A Yoshikawa T
%A Wada N
%A Hosoda T
%A Nii M
%A Tanaka K
%A Tanaka H
%A Kondo E
%A Takahashi Y
%A Ikeda T
%J Sci Rep
%V 14
%N 1
%D 2024 07 1
%M 38956291
%F 4.996
%R 10.1038/s41598-024-66027-8
%X The prenatal diagnosis of fetal heart disease potentially influences parental decision-making regarding pregnancy termination. Existing literature indicates that the severity, whether in complexity or lethality, significantly influences parental decisions concerning abortion. However, questions remain as to how fetal heart disease severity impacts parental decisions, given recent advancements in postsurgical outcomes. Therefore, we investigated risk factors associated with parents' decision-making regarding abortion following a prenatal diagnosis of fetal heart disease. Our analysis included 73 (terminated: n = 37; continued: n = 36) pregnancies with a fetal heart disease diagnosed before 22 weeks of gestation. Increased gestational age at diagnosis reduced the likelihood of parents' decision on termination (Model 1: adjusted odds ratio, 0.94; 95% confidence interval 0.89-0.99; Model 2: 0.95 0.90-0.997). Critical disease (5.25; 1.09-25.19) and concurrent extracardiac or genetic abnormalities (Model 1: 4.19, 1.21-14.53; Model 2: 5.47, 1.50-19.96) increased the likelihood of choosing abortion. Notably, complex disease did not significantly influence parental decisions (0.56; 0.14-2.20). These results suggest that parental decision-making regarding abortion may be influenced by earlier gestational age at diagnosis, the lethality of heart disease, and extracardiac or genetic abnormalities, but not its complexity if prenatal diagnosis and parental counseling are provided at a cardiovascular-specialized facility.