%0 Journal Article
%T Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity.
%A Russell J
%A Chen L
%A Liu A
%A Wang J
%A Ghosh S
%A Zhong X
%A Shi H
%A Beutler B
%A Nair-Gill E
%J EMBO Rep
%V 25
%N 8
%D 2024 Aug 2
%M 38956225
%F 9.071
%R 10.1038/s44319-024-00191-w
%X Signals emanating from the T-cell receptor (TCR), co-stimulatory receptors, and cytokine receptors each influence CD8 T-cell fate. Understanding how these signals respond to homeostatic and microenvironmental cues can reveal new ways to therapeutically direct T-cell function. Through forward genetic screening in mice, we discover that loss-of-function mutations in LDL receptor-related protein 10 (Lrp10) cause naive and central memory CD8 T cells to accumulate in peripheral lymphoid organs. Lrp10 encodes a conserved cell surface protein of unknown immunological function. T-cell activation induces Lrp10 expression, which post-translationally suppresses IL7 receptor (IL7R) levels. Accordingly, Lrp10 deletion enhances T-cell homeostatic expansion through IL7R signaling. Lrp10-deficient mice are also intrinsically resistant to syngeneic tumors. This phenotype depends on dense tumor infiltration of CD8 T cells, which display increased memory cell characteristics, reduced terminal exhaustion, and augmented responses to immune checkpoint inhibition. Here, we present Lrp10 as a new negative regulator of CD8 T-cell homeostasis and a host factor that controls tumor resistance with implications for immunotherapy.