%0 Systematic Review
%T Impact of frailty on post-operative outcomes following subarachnoid hemorrhage: A systematic review and meta-analysis.
%A Hamouda AM
%A Cwajna M
%A Elfil M
%A Derhab M
%A Desouki MT
%A Kobeissi H
%A Ghozy S
%A Kallmes DF
%J Clin Neurol Neurosurg
%V 244
%N 0
%D 2024 Sep 29
%M 38954868
%F 1.885
%R 10.1016/j.clineuro.2024.108413
%X <B>BACKGROUND: </B>Subarachnoid hemorrhage (SAH) is associated with high rates of mortality and morbidity, particularly among elderly patients. The presence of frailty may impact survival rates in patients with SAH. In this study, we aim to investigate the impact of frailty on the clinical outcomes in SAH patients.<BR><B>METHODS: </B>We conducted a systematic review and meta-analysis following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Relevant papers through December 2023 were retrieved from PubMed, Scopus, Web of science, and Embase.<BR><B>RESULTS: </B>A total of 5 studies met inclusion/exclusion criteria with an aggregate 39,221 non-frail patients (mean age 52.4 ± 5.2 yr; 62.1 % Female), and 79,416 frail patients (mean age 61.1 ± 5.4 yr; 69.0 % Female). Frailty was significantly associated with higher mortality ratio (Odds ratio (OR)= 2.09; CI [1.04: 4.20], p= 0.04), and increased length of hospital stay (OR= 1.40; CI [1.07: 1.83], p= 0.015). Additionally, frailty was associated with higher odds of external ventricular drain insertion, the need of tracheostomy/endoscopic gastrostomy, increased risk of deep vein thrombosis, and postoperative neurological complications.<BR><B>CONCLUSIONS: </B>Frailty is associated with worse clinical outcomes and higher mortality rates in SAH patients. Our findings highlight that frailty, when considered alongside other established prognostic factors, serves as crucial predictor for peri-operative complications and overall hospital course in SAH patients.