%0 Journal Article
%T A Prospective, Multicenter, Evaluator-Blinded, Randomized Study of Diluted Calcium Hydroxylapatite to Treat Decollete Wrinkles.
%A Pavicic T
%A Kerscher M
%A Kuhne U
%A Heide I
%A Dersch H
%A Odena G
%A Graul V
%J J Drugs Dermatol
%V 23
%N 7
%D 2024 Jul 1
%M 38954627
%F 1.608
%R 10.36849/JDD.8261
%X <B>BACKGROUND: </B>Calcium hydroxylapatite (CaHA) dermal filler is used for a variety of aesthetic treatments; however, the safety and effectiveness of diluted CaHA for the treatment of d&eacute;collet&eacute; wrinkles have not been established.<BR><B>OBJECTIVE: </B>To demonstrate the effectiveness and safety of diluted CaHA (Radiesse; 1:2 CaHA:saline) injection for the improvement of d&eacute;collet&eacute; wrinkles in females.<BR><B>METHODS: </B>Eligible females with moderate or severe ratings on the Merz Aesthetic Scale (MAS) Decollete Wrinkles - At Rest received up to 3 injection cycles of diluted CaHA either 8 weeks apart (3 injection cycles) or 16 weeks apart (2 injection cycles). Effectiveness was evaluated by improvement on the MAS. Adverse events were recorded over a 52 week period.<BR><B>RESULTS: </B>Sixteen weeks after the last treatment, the response rate (1-point improvement or greater) on the MAS Decollete Wrinkles - At Rest was 73.5% (P&lt;0.0001; pooled sample) for all patients. The use of diluted CaHA in the decollete also demonstrated a favorable safety profile.<BR><B>CONCLUSIONS: </B>Diluted CaHA is a safe and effective treatment for the improvement of decollete wrinkles in females.J Drugs Dermatol. 2024;23(7):551-556.&nbsp; doi:10.36849/JDD.8261.