%0 Journal Article
%T Surgery for Infrarenal Retroperitoneal Node Metastases from Colon Cancer.
%A Dulac AS
%A Genova P
%A Benoit O
%A Neuzillet C
%A Hajjam ME
%A Emile JF
%A Peschaud F
%A Lupinacci RM
%J J Gastrointest Cancer
%V 0
%N 0
%D 2024 Jul 2
%M 38954189
暂无%R 10.1007/s12029-024-01086-8
%X <B>OBJECTIVE: </B>Treatment of retroperitoneal lymph node metastases (RPN) from colon cancer (CC) is a therapeutic challenge. Available evidence supporting a curative approach is weak and uncertainties remain concerning the extent of the dissection, the optimal timing for surgery, and the role of adjuvant radiotherapy. We report the outcomes of a curative intent strategy in a recent monocentric series of patients.<BR><B>METHODS: </B>We did a retrospective review of all curative intent surgical treatment of RPN from CC performed consecutively in a French university hospital from June 2015 to April 2021. Demographics, clinicopathological, and molecular characteristics were evaluated. We describe recurrence-free and overall survival and factors related to recurrence.<BR><B>RESULTS: </B>Records from 18 patients were reviewed. The median age was 69 years. Most of the patients were male (55%), ASA 1-2 (94%), had a left-sided primary colon cancer (73%), and had metachronous RPN (62%). Thirteen patients (72%) experienced recurrence. Recurrence was often limited to RPN (27%) or liver (22%). Four patients underwent a second surgery for RPN recurrence. Median disease-free and overall survival were 22 months and 50 months after RPN surgery. We did not find any factor associated with recurrence. Short-term recurrence (< 6 months) was associated with shorter overall survival (0.031).<BR><B>CONCLUSIONS: </B>The current results suggest that RPN resection is feasible and associated with long survival in selected patients. Further studies evaluating the benefit of curative strategies including radical surgery for patients with potentially resectable RPN are warranted.