%0 Journal Article
%T Association Between Genes in the Nuclear Factor E2-Related Factor 2 Antioxidative Response Elements Pathway and Cancer-Related Fatigue in Women With Early-Stage Breast Cancer.
%A Davis TS
%A Koleck TA
%A Rosenzweig MQ
%A Miaskowski C
%A Erickson KI
%A Sereika SM
%A Bender CM
%A Conley YP
%J Oncol Nurs Forum
%V 51
%N 4
%D 2024 Jun 14
%M 38950096
%F 1.803
%R 10.1188/24.ONF.404-416
%X <B>OBJECTIVE: </B>To explore genes in the nuclear factor E2-related factor 2 antioxidative response elements (Nrf2-ARE) signaling pathway using a multiomics approach for associations with variability of cancer-related fatigue (CRF) in postmenopausal women with early-stage hormone receptor-positive breast cancer.<BR><B>UNASSIGNED: </B>Postmenopausal women (N = 116) with early-stage hormone receptor-positive breast cancer were recruited from western Pennsylvania.<BR><B>UNASSIGNED: </B>Candidate genes from the Nrf2-ARE pathway were investigated for associations with CRF occurrence and severity. Associations were evaluated using logistic regression for occurrence and linear regression for severity.<BR><B>RESULTS: </B>The rs2706110 TT genotype in NFE2L2 was associated with a 3.5-fold increase in odds of CRF occurrence. The cytosine-phosphate-guanine (CpG) site cg22820568 in PRDX1 was associated with CRF occurrence and severity.<BR><B>CONCLUSIONS: </B>Biomarkers based on Nrf2-ARE genes may help to identify women at increased risk for more severe CRF and to develop targeted interventions.