%0 Journal Article
%T Palpitations in Women With Breast Cancer Are Associated With Polymorphisms for Neurotransmitter Genes.
%A Sheng Y
%A Conley YP
%A Paul SM
%A Cooper BA
%A Carpenter JS
%A Hammer MJ
%A Levine JD
%A Miaskowski C
%J Oncol Nurs Forum
%V 51
%N 4
%D 2024 Jun 14
%M 38950091
%F 1.803
%R 10.1188/24.ONF.332-348
%X <B>OBJECTIVE: </B>To evaluate for associations between the occurrence of palpitations reported by women prior to breast cancer surgery and single nucleotide polymorphisms (SNPs) for neurotransmitter genes.<BR><B>UNASSIGNED: </B>A total of 398 women, who were scheduled for unilateral breast cancer surgery, provided detailed information on demographic and clinical characteristics and the occurrence of palpitations prior to breast cancer surgery.<BR><B>UNASSIGNED: </B>The occurrence of palpitations was assessed using a single item (i.e., "heart races/pounds" in the past week ["yes"/"no"]). Blood samples were collected for genomic analyses. Multiple logistic regression analyses were used to identify associations between the occurrence of palpitations and variations in neurotransmitter genes.<BR><B>RESULTS: </B>Nine SNPs and two haplotypes among 11 candidate genes were associated with the occurrence of palpitations. These genes encode for a number of neurotransmitters and/or their receptors, including serotonin, norepinephrine, dopamine, gamma-amino butyric acid, Substance P, and neurokinin.<BR><B>CONCLUSIONS: </B>These findings suggest that alterations in a variety of neurotransmitters contribute to the development of this symptom.