%0 Journal Article
%T Impact of pre-operative abdominal MRI on survival for patients with resected pancreatic carcinoma: a population-based study.
%A Alaref A
%A Siltamaki D
%A Cerasuolo JO
%A Akhtar-Danesh N
%A Caswell JM
%A Serrano PE
%A Meyers BM
%A Savage DW
%A Nelli J
%A Patlas M
%A Alabousi A
%A Siddiqui R
%A van der Pol CB
%J Lancet Reg Health Am
%V 35
%N 0
%D 2024 Jul
%M 38948322
暂无%R 10.1016/j.lana.2024.100809
%X <B>UNASSIGNED: </B>This study determined the impact of pre-operative abdominal MRI on all-cause mortality for patients with resected PDAC.<BR><B>UNASSIGNED: </B>All adult (≥18 years) PDAC patients who underwent pancreatectomy between January 2011 and December 2022 in Ontario, Canada, were identified for this population-based cohort study (ICD-O-3 codes: C250, C251, C252, C253, C257, C258). Patient demographics, comorbidities, PDAC stage, medical and surgical management, and survival data were sourced from multiple linked provincial administrative databases at ICES. All-cause mortality was compared between patients with and without a pre-operative abdominal MRI after controlling for multiple covariates.<BR><B>UNASSIGNED: </B>A cohort of 4579 patients consisted of 2432 men (53.1%) and 2147 women (46.9%) with a mean age of 65.2 years (standard deviation: 11.2 years); 2998 (65.5%) died while 1581 (34.5%) survived. Median follow-up duration post-resection was 22.4 months (interquartile range: 10.8-48.8 months), and median survival post-pancreatectomy was 25.9 months (95% confidence interval [95% CI]: 24.8, 27.5). Patients who underwent a pre-operative abdominal MRI had a median survival of 33.1 months (95% CI: 30.7, 37.2) compared to 21.1 months (95% CI: 19.8, 22.6) for all others. A total of 2354/4579 (51.4%) patients underwent a pre-operative abdominal MRI, which was associated with a 17.2% (95% CI: 11.0, 23.1) decrease in the rate of all-cause mortality, with an adjusted hazard ratio (aHR) of 0.828 (95% CI: 0.769, 0.890).<BR><B>UNASSIGNED: </B>Pre-operative abdominal MRI was associated with improved overall survival for PDAC patients who underwent pancreatectomy, possibly due to better detection of liver metastases than CT.<BR><B>UNASSIGNED: </B>Northern Ontario Academic Medicine Association (NOAMA) Clinical Innovation Fund.