%0 Journal Article
%T Vascular syk-ness: A new role for an old immunological favorite.
%A Fischer R
%J J Biol Chem
%V 300
%N 7
%D 2024 Jul 28
%M 38945448
暂无%R 10.1016/j.jbc.2024.107517
%X Acute respiratory distress syndrome (ARDS) is a deadly clinical presentation in sepsis, COVID, and other lung disorders where vascular fluid leakage is a severe problem. Recent findings by Shadab et al. in the JBC show that a well-known player in immune function, Syk, also regulates vascular leakage in response to sepsis. An existing FDA-approved inhibitor of Syk, fostamatinib, prevents the vascular leakage and improves survival in a mouse sepsis model, providing promise for ARDS treatment in the clinic.