%0 Journal Article
%T Python tooth-inspired fixation device for enhanced rotator cuff repair.
%A Kurtaliaj I
%A Hoppe ED
%A Huang Y
%A Ju D
%A Sandler JA
%A Yoon D
%A Smith LJ
%A Betancur ST
%A Effiong L
%A Gardner T
%A Tedesco L
%A Desai S
%A Birman V
%A Levine WN
%A Genin GM
%A Thomopoulos S
%J Sci Adv
%V 10
%N 26
%D 2024 Jun 28
%M 38941456
%F 14.957
%R 10.1126/sciadv.adl5270
%X Rotator cuff repair surgeries fail frequently, with 20 to 94% of the 600,000 repairs performed annually in the United States resulting in retearing of the rotator cuff. The most common cause of failure is sutures tearing through tendons at grasping points. To address this issue, we drew inspiration from the specialized teeth of snakes of the Pythonoidea superfamily, which grasp soft tissues without tearing. To apply this nondamaging gripping approach to the surgical repair of tendon, we developed and optimized a python tooth-inspired device as an adjunct to current rotator cuff suture repair and found that it nearly doubled repair strength. Integrated simulations, 3D printing, and ex vivo experiments revealed a relationship between tooth shape and grasping mechanics, enabling optimization of the clinically relevant device that substantially enhances rotator cuff repair by distributing stresses over the attachment footprint. This approach suggests an alternative to traditional suturing paradigms and may reduce the risk of tendon retearing after rotator cuff repair.