%0 Journal Article
%T Outcomes of Transcatheter Aortic Valve Replacement in Patients With Coexisiting Amyloidosis: Mortality, Stroke, and Readmission.
%A Elzeneini M
%A Gupta S
%A Assaf Y
%A Kumbhani DJ
%A Shah K
%A Grodin JL
%A Bavry AA
%J JACC Adv
%V 2
%N 2
%D 2023 Mar
%M 38938319
暂无%R 10.1016/j.jacadv.2023.100255
%X <B>UNASSIGNED: </B>Cardiac amyloidosis can coexist in patients with severe aortic stenosis. There are limited outcomes data on whether this impacts the risk of transcatheter aortic valve replacement (TAVR).<BR><B>UNASSIGNED: </B>The authors aimed to investigate the effect of amyloidosis on outcomes of TAVR.<BR><B>UNASSIGNED: </B>We used the Nationwide Readmissions Database to identify hospitalizations for TAVR between 2016 and 2019. The presence of a diagnosis of amyloidosis was identified. Propensity score-weighted regression analysis was used to identify the association of amyloidosis with in-hospital mortality, acute ischemic stroke, and 30-day readmission rate after TAVR.<BR><B>UNASSIGNED: </B>We identified 245,020 hospitalizations for TAVR, including 273 in patients with amyloidosis. The mean age was 79.4 ± 8.4 years. There was no difference in in-hospital mortality or 30-day readmission rate in patients with and without amyloidosis (1.8% vs 1.5%, P = 0.622; and 12.9% vs 12.5%, P = 0.858; respectively). However, there was a higher rate of acute ischemic stroke in patients with amyloidosis (6.2% vs 1.8%, P < 0.001). Propensity score-weighted logistic regression analysis showed the presence of amyloidosis was associated with greater odds of acute ischemic stroke (odds ratio: 3.08, 95% CI: 1.41-6.71, P = 0.005), but no difference in mortality (odds ratio: 0.79, 95% CI: 0.28-2.27, P = 0.666) or 30-day readmission rate after TAVR (HR: 0.72, 95% CI: 0.41-1.25, P = 0.241).<BR><B>UNASSIGNED: </B>This analysis suggests amyloidosis may be associated with a higher thromboembolic risk after TAVR that merits further investigation.