%0 Journal Article %T Unraveling host genetics and microbiome genome crosstalk: a novel therapeutic approach. %A Zhang Q %A Schwarz D %A Cheng Y %A Sohrabi Y %J Trends Mol Med %V 0 %N 0 %D 2024 Jun 27 %M 38937208 %F 15.272 %R 10.1016/j.molmed.2024.06.007 %X The ability of the gut microbiome to adapt to a new environment and utilize a new metabolite or dietary compound by inducing structural variations (SVs) in the genome has an important role in human health. Here, we discuss recent data on host genetic regulation of SV induction and its use as a new therapeutic approach.