%0 Journal Article
%T Effects of an Intervention to Improve Evidence-Based Care for People With Diabetes and Cardiovascular Disease Across Sex, Race, and Ethnicity Subgroups: Insights From the COORDINATE-Diabetes Trial.
%A Tannu M
%A Kaltenbach L
%A Pagidipati NJ
%A McGuire DK
%A Aroda VR
%A Pop-Busui R
%A Kondamudi N
%A Al-Khalidi HR
%A Lopes RD
%A Cavender MA
%A Nelson AJ
%A Kirk J
%A Lingvay I
%A Magwire M
%A Richardson CR
%A Webb L
%A Leyva M
%A Pandey A
%A Washington A
%A Pak J
%A Gaynor T
%A Khan W
%A Weston P
%A Granger CB
%A Green J
%J Circulation
%V 0
%N 0
%D 2024 Jun 27
%M 38934111
%F 39.918
%R 10.1161/CIRCULATIONAHA.124.068962
%X <B>UNASSIGNED: </B>Results from the COORDINATE-Diabetes trial demonstrated that a multifaceted, clinic-based intervention increased prescription of evidence-based medical therapies to participants with type 2 diabetes and atherosclerotic cardiovascular disease. This secondary analysis assessed whether intervention success was consistent across sex, race, and ethnicity.<BR><B>UNASSIGNED: </B>COORDINATE-Diabetes, a cluster randomized trial, recruited participants from 43 US cardiology clinics (20 randomized to intervention and 23 randomized to usual care). The primary outcome was the proportion of participants prescribed all 3 groups of evidence-based therapy (high-intensity statin, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, and sodium-glucose cotransporter-2 inhibitor or glucagon-like peptide 1 receptor agonist) at last trial assessment (6 to 12 months). In this prespecified analysis, mixed-effects logistic regression models were used to assess the outcome by self-reported sex, race, and ethnicity in the intervention and usual care groups, with adjustment for baseline characteristics, medications, comorbidities, and site location.<BR><B>UNASSIGNED: </B>Among 1045 participants with type 2 diabetes and atherosclerotic cardiovascular disease, the median age was 70 years, 32% were female, 16% were Black, and 9% were Hispanic. At the last trial assessment, there was an absolute increase in the proportion of participants prescribed all 3 groups of evidence-based therapy in women (36% versus 15%), Black participants (41% versus 18%), and Hispanic participants (46% versus 18%) with the intervention compared with usual care, with consistent benefit across sex (male versus female; Pinteraction=0.44), race (Black versus White; Pinteraction=0.59), and ethnicity (Hispanic versus Non-Hispanic; Pinteraction= 0.78).<BR><B>UNASSIGNED: </B>The COORDINATE-Diabetes intervention successfully improved delivery of evidence-based care, regardless of sex, race, or ethnicity. Widespread dissemination of this intervention could improve equitable health care quality, particularly among women and minority communities who are frequently underrepresented in clinical trials.<BR><B>UNASSIGNED: </B>URL: https://clinicaltrials.gov. Unique identifier: NCT03936660.