%0 Journal Article
%T Comprehensive Analysis of Novel Synergistic Antioxidant Formulations: Insights into Pharmacotechnical, Physical, Chemical, and Antioxidant Properties.
%A Neacșu SM
%A Mititelu M
%A Ozon EA
%A Musuc AM
%A Iuga IDM
%A Manolescu BN
%A Petrescu S
%A Pandele Cusu J
%A Rusu A
%A Surdu VA
%A Oprea E
%A Lupuliasa D
%A Popescu IA
%J Pharmaceuticals (Basel)
%V 17
%N 6
%D 2024 May 27
%M 38931357
%F 5.215
%R 10.3390/ph17060690
%X (1) Background: Oxidative stress plays a pivotal role in the pathogenesis of various diseases, including neurodegenerative disorders, cardiovascular diseases, cancer, and diabetes, highlighting the pressing need for effective antioxidant interventions. (2) Methods: In this study, we aimed to develop and characterise two novel antioxidant formulations, F3 and F4, as therapeutic interventions for oxidative stress-related conditions. (3) Results: The physicochemical characterisation, preformulation analysis, formulation, preparation of filling powders for capsules, capsule content evaluation, and antioxidant activity assessment of the two novel antioxidant formulations were assessed. These formulations comprise a combination of well-established antioxidants like quercetin, biotin, coenzyme Q10, and resveratrol. Through comprehensive testing, the formulations' antioxidant efficacy, stability, and potential synergistic interactions were evaluated. (4) Conclusions: The findings underscore the promising potential of these formulations as therapeutic interventions for oxidative stress-related disorders and highlight the significance of antioxidant interventions in mitigating their progression.