%0 Journal Article %T Ancient Mitochondrial Genomes Provide New Clues in the History of the Akhal-Teke Horse in China. %A Zhu S %A Zhang N %A Zhang J %A Shao X %A Guo Y %A Cai D %J Genes (Basel) %V 15 %N 6 %D 2024 Jun 15 %M 38927726 %F 4.141 %R 10.3390/genes15060790 %X This study analyzed ancient DNA from the remains of horses unearthed from the Shihuyao tombs. These were found to date from the Han and Tang Dynasties in Xinjiang (approximately 2200 to 1100 years ago). Two high-quality mitochondrial genomes were acquired and analyzed using next-generation sequencing. The genomes were split into two maternal haplogroups, B and D, according to a study that included ancient and contemporary samples from Eurasia. A close genetic affinity was observed between the horse of the Tang Dynasty and Akhal-Teke horses according to the primitive horse haplotype G1. Historical evidence suggests that the ancient Silk Road had a vital role in their dissemination. Additionally, the matrilineal history of the Akhal-Teke horse was accessed and suggested that the early domestication of the breed was for military purposes.