%0 Journal Article
%T Neuronal Cell Differentiation of iPSCs for the Clinical Treatment of Neurological Diseases.
%A Lee DH
%A Lee EC
%A Lee JY
%A Lee MR
%A Shim JW
%A Oh JS
%J Biomedicines
%V 12
%N 6
%D 2024 Jun 18
%M 38927557
%F 4.757
%R 10.3390/biomedicines12061350
%X Current chemical treatments for cerebrovascular disease and neurological disorders have limited efficacy in tissue repair and functional restoration. Induced pluripotent stem cells (iPSCs) present a promising avenue in regenerative medicine for addressing neurological conditions. iPSCs, which are capable of reprogramming adult cells to regain pluripotency, offer the potential for patient-specific, personalized therapies. The modulation of molecular mechanisms through specific growth factor inhibition and signaling pathways can direct iPSCs' differentiation into neural stem cells (NSCs). These include employing bone morphogenetic protein-4 (BMP-4), transforming growth factor-beta (TGFβ), and Sma-and Mad-related protein (SMAD) signaling. iPSC-derived NSCs can subsequently differentiate into various neuron types, each performing distinct functions. Cell transplantation underscores the potential of iPSC-derived NSCs to treat neurodegenerative diseases such as Parkinson's disease and points to future research directions for optimizing differentiation protocols and enhancing clinical applications.