%0 Journal Article
%T Surgical and radiosurgical treatment of hypothalamic hamartoma: The Italian experience between 2011 and 2021.
%A Rizzi M
%A Consales A
%A Tramacere I
%A De Benedictis A
%A Bua A
%A Specchio N
%A De Palma L
%A Cognolato E
%A Nobili L
%A Tortora D
%A Barba C
%A Pommella M
%A Giordano F
%A Pastori C
%A Marchetti M
%A Garbelli R
%A Zucchelli M
%A Martinoni M
%A Ferri L
%A Martucci M
%A Tamburrini G
%A Bianchi F
%A Passamonti C
%A Di Gennaro G
%A Villani F
%A Tassi L
%A Marras C
%J Epilepsia Open
%V 0
%N 0
%D 2024 Jun 26
%M 38926936
%F 4.026
%R 10.1002/epi4.12989
%X <B>OBJECTIVE: </B>To investigate the Italian experience on the surgical and radiosurgical treatment of drug-resistant epilepsy due to hypothalamic hamartoma (HH) in the period 2011-2021 in six Italian epilepsy surgery centers, and to compare safety and efficacy profiles of the different techniques.<BR><B>METHODS: </B>We collected pseudo-anonymized patient's data with at least 12 months of follow-up. Surgical outcome was defined according to Engel classification of seizure outcome. Univariate analysis was performed to assess the risk of post-operative seizures, categorized in dichotomous variable as favorable and unfavorable; explanatory variables were considered. Mann-Whitney or Chi-squared test were used to assess the presence of an association between variables (p < 0.05).<BR><B>RESULTS: </B>Full presurgical and postoperative data about 42 patients from 6 epilepsy surgery centers were gathered. Engel class I was reached in the 65.8% and 66.6% of patients with gelastic and non-gelastic seizures, respectively. Other than daily non-gelastic seizures were associated with seizure freedom (p = 0.01), and the radiological type presented a trend toward significance (p = 0.12).<BR><B>CONCLUSIONS: </B>Endoscopic disconnection and laser interstitial thermal therapy are effective in the treatment of HH-related epilepsy, with a tolerable safety profile. Both gelastic and non-gelastic seizures can be treated, also in patients with a long history of seizures.<BR><B>CONCLUSIONS: </B>This study collected data about 42 patients with HH-related epilepsies. Endoscopic disconnection and laser therapy are both effective and safe in the treatment of hypothalamic hamartoma-related epilepsies.