%0 Journal Article %T Pathology of Squamous Cell Carcinoma of the Penis: Back to Square One. %A Sanchez DF %A Oliveira P %J Urol Clin North Am %V 51 %N 3 %D 2024 Aug %M 38925734 %F 2.766 %R 10.1016/j.ucl.2024.03.003 %X The landscape of squamous cell carcinoma of the penis (SCC-P) has undergone a significant transformation since the new World Health Organization classification of genitourinary cancers and recent European Association of Urology/American Association of Clinical Oncology guidelines. These changes emphasize the necessity to categorize SCC-P into 2 groups based on its association with human papillomavirus (HPV) infection. This shift has major implications, considering that prior knowledge was derived from a mix of both groups. Given the distinct prognosis, treatment options, and staging systems observed for HPV-associated tumors in other body areas, the question now arises: will similar patterns emerge for SCC-P?