%0 Journal Article
%T The Impact of Lifestyle on Cardiovascular Risk in Patients with Gout: a Population-based Cohort Study.
%A Jung SM
%A Jung SH
%A Lee SN
%A Choi JA
%A Kim D
%A Won HH
%A Kim KJ
%A Yun JS
%J Eur Heart J Qual Care Clin Outcomes
%V 0
%N 0
%D 2024 Jun 26
%M 38925656
%F 7.064
%R 10.1093/ehjqcco/qcae048
%X <B>OBJECTIVE: </B>Gout is associated with a significant burden of cardiovascular disease. The aim of this study was to evaluate the impact of a favorable lifestyle on incident cardiovascular events in patients with gout.<BR><B>METHODS: </B>We identified 9 110 patients with gout from the UK Biobank cohort based on self-report and/or hospital diagnostic codes. Lifestyle behaviors, including smoking status, physical activity, obesity, and diet, were categorized into three patterns: favorable (3-4 healthy factors), intermediate (2 healthy factors), and unfavorable (0-1 healthy factor). The cardiovascular risk of participants with and without gout was estimated based on their serum uric acid levels and lifestyle patterns.<BR><B>RESULTS: </B>Among 9 110 patients with gout and 457 596 participants without gout, the median follow-up duration was 8.9 years. The incidence rate of cardiovascular disease was significantly higher in the gout population than in the non-gout population (11.38 vs 5.49 per 1000 person-years). The gout population consistently exhibited a high cardiovascular risk, irrespective of uric acid levels, whereas a positive correlation was observed between uric acid levels and cardiovascular risk in the non-gout population. Adopting a favorable lifestyle pattern was associated with a lower risk of cardiovascular disease in both gout and non-gout populations. Across all categories of uric acid, a favorable lifestyle was found to reduce cardiovascular risk in patients with gout.<BR><B>CONCLUSIONS: </B>Patients with gout remain at high risk of developing cardiovascular disease despite having normal uric acid levels. Lifestyle modifications may represent an effective and cost-efficient therapeutic approach for preventing cardiovascular events in this population.