%0 Journal Article
%T Effects of 2 months of methylphenidate on energy expenditure in individuals with obesity: A randomized, double-blind, placebo-controlled pilot study.
%A McInnis K
%A Doucet É
%A Hafizi K
%A El Amine F
%A Heidinger B
%A Cameron JD
%A BaniFatemi S
%A Robaey P
%A Vaillancourt R
%A Goldfield GS
%J Physiol Rep
%V 12
%N 12
%D 2024 Jun
%M 38924673
暂无%R 10.14814/phy2.16085
%X Methylphenidate (MPH) has been previously shown to increase resting energy expenditure (REE) in individuals of normal weight; however, the effects on individuals living with obesity are currently unknown. Ten individuals living with obesity were randomly assigned to undergo 60 days of MPH administration with a daily dose of 0.5 mg/kg body weight or a placebo control. REE was measured before and after the 60-day intervention. There was a trend toward significance for group × time interaction on REE (p = 0.082) with a large effect size (η2 = 0.331), with MPH administration increasing REE compared to a decrease in placebo control. Preliminary findings from this pilot study show that MPH has the potential to counter the adaptive thermogenic process commonly seen in weight loss. This is a unique finding among pharmacotherapies, as no approved obesity drugs measurably impact REE.