%0 Journal Article
%T Long-Term Outcomes After Lung Transplantation in Children With Intellectual Disabilities.
%A Lee JY
%A Mullis DM
%A Zawadzki RS
%A Nilkant R
%A Kuhan S
%A Kidambi S
%A Sharir A
%A Ma M
%J Pediatr Transplant
%V 28
%N 5
%D 2024 Aug
%M 38923151
%F 1.551
%R 10.1111/petr.14807
%X <B>BACKGROUND: </B>The United Network for Organ Sharing (UNOS) started recording data on intellectual disability status in 2008. This study aimed to characterize the long-term outcomes for children with intellectual disabilities (IDs) undergoing lung transplantation.<BR><B>METHODS: </B>All pediatric patients (under 18 years old) undergoing bilateral lung transplantation were identified using the UNOS database. The patients were grouped into the following categories: no cognitive delay, possible cognitive delay, and definite cognitive delay. The primary endpoint was graft survival at 3-year posttransplantation. Multivariate Cox proportional hazards modeling was used to estimate the independent effect of cognitive disability on graft survival.<BR><B>RESULTS: </B>Five hundred four pediatric patients who underwent lung transplantation between March 2008 and December 2022 were retrospectively analyzed. 59 had a definite cognitive delay (12%), 23 had a possible delay (5%), and 421 had no delay (83%). When comparing these three groups, there was no significant difference in 60-day graft survival (p = 0.4), 3-year graft survival (p = 0.6), 3-year graft survival for patients who survived at least 60-day posttransplantation (p = 0.9), distribution of causes of death (p = 0.24), nor distribution treatment of rejection within 1-year posttransplantation (p = 0.06).<BR><B>CONCLUSIONS: </B>Intellectual disability does not impact long-term outcomes after bilateral lung transplantation. Intellectual disability should not be a contraindication to bilateral lung transplantation on the basis of inferior graft survival.