%0 Journal Article
%T Design Principles for Immunomodulatory Biomaterials.
%A Oluwole SA
%A Weldu WD
%A Jayaraman K
%A Barnard KA
%A Agatemor C
%J ACS Appl Bio Mater
%V 0
%N 0
%D 2024 Jun 26
%M 38922334
暂无%R 10.1021/acsabm.4c00537
%X The immune system is imperative to the survival of all biological organisms. A functional immune system protects the organism by detecting and eliminating foreign and host aberrant molecules. Conversely, a dysfunctional immune system characterized by an overactive or weakened immune system causes life-threatening autoimmune or immunodeficiency diseases. Therefore, a critical need exists to develop technologies that regulate the immune system to ensure homeostasis or treat several diseases. Accumulating evidence shows that biomaterials─artificial materials (polymers, metals, ceramics, or engineered cells and tissues) that interact with biological systems─can trigger immune responses, offering a materials science-based strategy to modulate the immune system. This Review discusses the expanding frontiers of biomaterial-based immunomodulation, focusing on principles for designing these materials. This Review also presents examples of immunomodulatory biomaterials, which include polymers and metal- and carbon-based nanomaterials, capable of regulating the innate and adaptive immune systems.