%0 Case Reports %T Effective Endoscopic Submucosal Dissection of a Huge Esophageal Liposarcoma: A Case Report. %A Lee MJ %A Lee MW %A Joo DC %A Hong SM %A Baek DH %A Lee BE %A Kim GH %A Song GA %J Korean J Gastroenterol %V 83 %N 6 %D 2024 Jun 25 %M 38918037 暂无%R 10.4166/kjg.2024.047 %X This case report presents the successful endoscopic submucosal dissection (ESD) of a well-differentiated esophageal liposarcoma in a 51-year-old male with persistent dysphagia. The cause was initially diagnosed as a 10 cm pedunculated lesion extending from the upper esophageal sphincter to the mid-esophagus. An ESD was chosen over traditional surgery because it is less invasive. The procedure involved a precise submucosal injection and excision with special techniques to manage bleeding from a central vessel. Despite the extraction challenges owing to the size of the lesion, it was successfully removed orally. A histopathological examination of the 8.3×4.2×2.3 cm specimen revealed the characteristic features of a well-differentiated liposarcoma, including MDM2 and CDK4 positivity. The follow-up revealed no recurrence, and active surveillance has been performed since. This report highlights the versatility of ESD in treating significant esophageal tumors and provides evidence for its efficacy as a minimally invasive alternative.