%0 Journal Article
%T Risk of Fractures Following Bariatric Surgery with Roux-en-Y gastric Bypass or Sleeve Gastrectomy: A Danish Population-based Cohort Study.
%A Winckelmann LA
%A Gribsholt SB
%A Bødkergaard K
%A Rejnmark L
%A Madsen LR
%A Richelsen B
%J Eur J Endocrinol
%V 0
%N 0
%D 2024 Jun 25
%M 38916995
%F 6.558
%R 10.1093/ejendo/lvae068
%X <B>OBJECTIVE: </B>We examined the association between Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) and fracture risk, including major osteoporotic fractures (MOF), and the use of anti-osteoporosis medication (AOM). While RYGB is associated with impaired bone health and increased fracture risk, it remains uncertain whether SG has a similar impact, and whether this risk is primarily due to MOF or any fracture.<BR><B>METHODS: </B>We conducted a nationwide cohort study covering patients treated with RYGB (n=16,121, 10.2 years follow-up) or SG (n=1,509, 3.7 years follow-up), from 2006-2018, comparing them to an age- and sex-matched cohort (n=407,580).<BR><B>METHODS: </B>We computed incidence rates and adjusted hazard ratios (HR) with 95% confidence intervals (CIs), using Cox regression for any fracture, MOF, and use of AOM with adjustment for comorbidities.<BR><B>RESULTS: </B>Compared to the general population cohort, RYGB was associated with an increased risk of any fracture (HR 1.56 [95% CI: 1.48; 1.64]) and MOF (HR 1.49 [1.35; 1.64]). SG was associated with an increased risk of any fracture (HR 1.38 [1.13; 1.68]), while the HR of MOF was 1.43 [0.97; 2.12]. The use of AOM was low but similar in all cohorts (approximately 1%).<BR><B>CONCLUSIONS: </B>Bariatric surgery increased the risk of any fracture and MOF to similar extend. Risks were similar for RYGB and SG. However, SG had a shorter follow-up than RYGB, and the cohort size was rather small. More research is needed for long-term SG fracture risk assessment. The use of AOM was low in all cohorts.