%0 Journal Article
%T Dry eye and decreased tear film stability in primary acquired nasolacrimal duct obstruction patients.
%A Yu X
%A Wang K
%A Hu Y
%A Meng Z
%A Li J
%A Liu Y
%A Xiao L
%A Chen M
%A Li S
%A Shen Y
%A Chen R
%A Liang X
%J Int Ophthalmol
%V 44
%N 1
%D 2024 Jun 25
%M 38916702
%F 2.029
%R 10.1007/s10792-024-03204-8
%X <B>OBJECTIVE: </B>Exploring the prevalence of dry eye (DE) and the changes of tear film stability in patients with primary acquired obstruction of the nasolacrimal duct (PANDO).<BR><B>METHODS: </B>In this cross-sectional, observational study, 370 eyes in 223 patients with PANDO were assessed. The ocular surface disease index (OSDI) was used to evaluate ocular surface symptoms, and the Keratograph 5M non-invasive ocular surface analyser was used to assess ocular surface parameters. According to the TFOS DEWS II criteria, patients with OSDI ≥ 13 and NIKBUT < 10 s were diagnosed with DE.<BR><B>RESULTS: </B>Of the 223 PANDO patients, 65 (29.1%) met the diagnostic criteria for DE. Compared with patients without DE, PANDO patients with DE were significantly older (p < 0.001), had a longer duration of epiphora (p = 0.023), and more likely to have a positive regurgitation on pressure over the lacrimal sac (ROPLAS) sign (p = 0.003). Multifactorial analysis showed that older age, positive ROPLAS and hypertension were significant independent predictors of DE (p < 0.05). Among the 147 unilateral PANDO patients without DE, the TMH, NIKBUT-first, NIKBUT-average and bulbar erythema scores were significantly higher in the PANDO sides.<BR><B>CONCLUSIONS: </B>This study illustrated the prevalence of DE in PANDO patients was 29.1% and DE is more likely to occur in those who are older, have hypertension and are positive for ROPLAS. In addition, in patients with unilateral nasolacrimal duct obstruction, a decrease in tear film stability was observed in the healthy eye.