%0 Journal Article
%T Nanofabrication of Losartan Potassium Sustained Release Floating Microspheres Using Different Grades of Ethyl Cellulose and Its Insight on Release Profiles.
%A Rajput T
%A Mohite DP
%A Ghule S
%A Vinchurkar K
%A Singh S
%J Curr Pharm Des
%V 0
%N 0
%D 2024 Jun 20
%M 38910484
%F 3.31
%R 10.2174/0113816128309675240530060752
%X <B>BACKGROUND: </B>A sustained release system for losartan potassium designed to delay its residence time in the stomach through the preparation of solvent evaporation technique-based floating microspheres. The influence of the different grades of Ethocel™ such as 4 cps, 10 cps, and 22 cps as well as the drug: polymer ratio on various properties of microspheres were tested.<BR><B>METHODS: </B>Thermal and functional analysis revealed no interaction between the encapsulated drug and polymer. The results indicated that the mean diameter of microspheres increased with a change in grades of ethyl cellulose relating to viscosity. However, the drug incorporation efficiency within ethyl cellulose microspheres decreased with increasing viscosity of ethyl cellulose.<BR><B>RESULTS: </B>The bulk density of the formulations was proportionally dependent on concentration and the viscosity of the polymer, which resulted in a decrease in floating capacity from 90.02% to 73.58%. Moreover, the drug release was indirectly proportional to the viscosity of ethyl cellulose tested. The in vitro release profile exhibited a burst effect with a biphasic release pattern following Fickian diffusion, indicating a diffusioncontrolled release mechanism.<BR><B>CONCLUSIONS: </B>The results demonstrated that the viscosity of ethyl cellulose significantly affects the floating capacity and drug release pattern from microspheres.