%0 Journal Article
%T Real-world experiences of migraine patients on Erenumab: a Kuwait single center cohort.
%A Al-Hashel JY
%A Alroughani R
%A Alshaf F
%A Ashkanani HK
%A Akl A
%A AlMutairi O
%A Alwazzan S
%A Ahmed SF
%J Neurol Res
%V 0
%N 0
%D 2024 Jun 23
%M 38909320
%F 2.529
%R 10.1080/01616412.2024.2354618
%X <B>UNASSIGNED: </B>Migraine is a prevalent headache disorder with a significant impact on the quality of life. This study aims to investigate the effectiveness and safety of erenumab, mAb targeting the CGRP receptor, in treating chronic (CM) and episodic (EM) migraine in clinical practice Kuwait, providing region-specific insights to treatment options.<BR><B>UNASSIGNED: </B>This was a prospective observational cohort study of patients diagnosed with EM or CM treated with erenumab. The primary outcome of the study was to assess the proportion of patients achieving ≥ 50% reduction in monthly mean migraine days, and several changes including the mean number of monthly migraine days, the frequency of analgesic use, attack severity, AEs, and QoL.<BR><B>UNASSIGNED: </B>The study included 151 patients with a mean age of 44.0±11.4 years, and 81.9% female. The primary outcome was achieved in 74.2% of patients, with a significant (p < 0.001) reduction in headache frequency, pain severity, analgesic use, and improvement in QoL. Age and duration of migraine were significant predictors of achieving a ≥ 50% reduction in headache frequency after therapy (OR = 0.955; p = 0.009) and (OR = 0.965; p = 0.025), respectively. Treatment compliance was observed in 76.2% of patients, and 24.5% discontinued treatment. Constipation was the most commonly reported AEs (6.0%), and conservative management was the most common approach to managing AEs.<BR><B>UNASSIGNED: </B>Erenumab was effective in reducing the frequency and severity of migraine attacks and improving QoL, and safe with manageable AEs in a real-world setting in Kuwait. Further research is needed to better understand erenumab's effectiveness and safety in different populations and settings, as well as to compare it with other migraine prophylactic treatments.