%0 Journal Article
%T Prevention of cardiotoxicity in childhood cancer survivors: In physical exercise, we trust.
%A Bucciarelli V
%A Bianco F
%A Bisaccia G
%A Galanti K
%A Arata A
%A Ricci M
%A Bucciarelli B
%A Marinelli M
%A Renda G
%A Farinetti A
%A Mattioli AV
%A Gallina S
%J Curr Probl Cardiol
%V 49
%N 9
%D 2024 Sep 20
%M 38908726
%F 16.464
%R 10.1016/j.cpcardiol.2024.102722
%X In recent years, the mean survival rate of children after a cancer diagnosis has significantly improved. At the same time, a growing interest in short and long-term cardiovascular (CV) complications of cancer therapy, as well as long-term CV risk in childhood cancer survivors (CCS) developed, along with proposals of protocols for the diagnosis, management, and prevention of cancer therapy-related CV toxicity (CTR-CVT) in this population. Many clinical and individual risk factors for CTR-CVT have been identified, and a non-negligible prevalence of traditional CV risk factors has been described in this population, potentially associated with a further worsening in both CTR-CVT and long-term CV risk. Physical exercise (PE) represents a promising, free-of-cost and free-of-complications, helpful therapy for primary and secondary prevention of CTR-CVT in CCS. The present narrative review aims to summarize the most critical evidence available about CTR-CVT in CCS, focusing on the role of PE in this clinical scenario.