%0 Journal Article
%T Targeted discovery of unusual diterpenoids with anti-fungal activity from the root of Euphorbia lathyris.
%A Wang Y
%A Xu S
%A Zhang G
%A Li P
%A Liu C
%A Zhou J
%A Feng X
%A Li L
%A Chen Y
%J Phytochemistry
%V 225
%N 0
%D 2024 Jun 20
%M 38908463
%F 4.004
%R 10.1016/j.phytochem.2024.114193
%X Lathyrisone A (1), a diterpene with an undescribed tricyclic 6/6/6 fused carbon skeleton, along with spirolathyrisins B-D (3-5), three diterpenes with a rare [4.5.0] spirocyclic carbon skeleton, and one known compound (2) were isolated from the roots of Euphorbia lathyris. Their chemical structures were characterized by extensive spectroscopic analysis, X-ray crystallography, ECD and quantum chemistry calculation. A plausible biosynthetic pathway for compounds 1-5 was proposed, which suggested it is a competitive pathway for ingenol biosynthesis in the plant. The anti-fungal activities of these compounds were tested, especially, compound 2 showed stronger anti-fungal activities against Fusarium oxysporum and Alternaria alternata than the positive control fungicide thiophanate-methyl. The preliminary structure-activity relationship of compounds 1-5 was also discussed. These results not only expanded the chemical diversities of E. lathyris, but also provided a lead compound for the control of plant pathogens.