%0 Journal Article
%T Disulfiram-loaded CuO2 nanocarriers for enhanced synergistic chemodynamic chemotherapy.
%A Hu W
%A Yang L
%A Liao H
%A Sun D
%A Ouyang XK
%A Wang N
%A Yang G
%J J Colloid Interface Sci
%V 674
%N 0
%D 2024 Jun 21
%M 38908062
%F 9.965
%R 10.1016/j.jcis.2024.06.147
%X Disulfiram (DSF) metabolites exhibit antitumor properties when bound to Cu2+. This combination also promotes the generation of reactive oxygen species (ROS), ultimately leading to tumor cell death. In this study, CuO2 served as a carrier for DSF, forming a dual-drug delivery system with Cu2+ and DSF encapsulated in polydopamine (PDA). In the final delivery system, CuO2 (DSF-CuO2@PDA) was hydrolyzed at the tumor site, releasing both Cu2+ and H2O2. Cu2+ reacts with DSF metabolites to form Bis(diethyldithiocarbamate)-Cu (CuET), which triggers a Fenton-like reaction that generates ROS. Chemotherapy and chemodynamic therapy exhibited significant tumor-suppressive capabilities, with an inhibition rate of 61 %. In addition, the DSF-CuO2@PDA complex demonstrated superlative tumor-targeting ability and biocompatibility.