%0 Journal Article %T Effect of geometrical design variables on implantation configuration and fixation stiffness of titling bone anchors: A parametric finite element study. %A Abedi A %A Farahmand F %A Zanjani LO %A Nabian MH %J Med Eng Phys %V 129 %N 0 %D 2024 07 %M 38906573 %F 2.356 %R 10.1016/j.medengphy.2024.104191 %X The mechanical interaction of a tilting anchor and cancellous bones of various densities was simulated using finite element modeling. The model enjoyed a sophisticated representation of the bone, as an elasto-plastic material with large deformation capability. The anchor's tilting action during implantation phase, as well as its fixation stiffness during pull-out test, were predicted by the model and a parametric study was performed to investigate the effects of the anchor's distal width and corner fillet radius, on these measures. The model predictions were validated against the results of an experimental test on ovine humerus specimens. The model could reasonably reproduce the tilting action of the anchor during the implantation phase. Comparison of the model predictions with the experimental results revealed similar trends during both the implantation and the pull-out phases, but smaller displacement magnitudes (end points: 1.4 vs. 2.1 mm and 4.6 vs. 5.2 mm, respectively). The results of the parametric study indicated substantial increase in the fixation stiffness with increasing bone density. Reducing the distal width and increasing the fillet radius improved the anchor's implantation configuration and fixation stiffness in low-density bones. For high-density bone applications, however, a larger distal width was favored for improving the fixation stiffness.