%0 Journal Article
%T Phenylphenalenones and Linear Diarylheptanoid Derivatives Are Biosynthesized via Parallel Routes in Musella lasiocarpa, the Chinese Dwarf Banana.
%A Lyu H
%A Ernst L
%A Nakamura Y
%A Okamura Y
%A Köllner TG
%A Luck K
%A Liu B
%A Chen Y
%A Beerhues L
%A Gershenzon J
%A Paetz C
%J Org Lett
%V 26
%N 26
%D 2024 Jul 5
%M 38900928
%F 6.072
%R 10.1021/acs.orglett.4c01750
%X Here, we use transcriptomic data from seeds of Musella lasiocarpa to identify five enzymes involved in the formation of dihydrocurcuminoids. Characterization of the substrate specificities of the enzymes reveals two distinct dihydrocurcuminoid pathways leading to phenylphenalenones and linear diarylheptanoid derivatives, the major seed metabolites. Furthermore, we demonstrate the stepwise conversion of dihydrobisdemethoxycurcumin to the phenylphenalenone 4'-hydroxylachnanthocarpone by feeding intermediates to M. lasiocarpa root protein extract.