%0 Case Reports
%T Nonhealing Surgical Wounds in a Patient with Plasminogen Deficiency Type 1 Successfully Treated with Intravenous Plasminogen: A Case Report.
%A Decker RW
%A Parker JM
%A Lorber J
%A Crea R
%A Thibaudeau K
%J Adv Skin Wound Care
%V 37
%N 7
%D 2024 Jul 1
%M 38899821
%F 2.373
%R 10.1097/ASW.0000000000000160
%X <B>UNASSIGNED: </B>Intravenous plasminogen replacement therapy for patients with plasminogen deficiency type 1 (hypoplasminogenemia) was recently approved for marketing in the US. In this case report, the authors describe a 33-year-old man with hypoplasminogenemia who developed nonhealing postsurgical wounds following trauma to his right hand despite receiving standard treatment for 4 months. The patient was enrolled in a compassionate-use protocol with intravenous plasminogen replacement therapy and experienced prompt resolution of surgical wounds. He was the first human patient to receive replacement therapy with plasminogen, human-tvmh in the US and first to demonstrate cutaneous wound healing in addition to resolution of ligneous lesions attributable to plasminogen deficiency type 1.