%0 Journal Article %T 6th and 7th International consensus guidelines for the management of advanced breast cancer (ABC guidelines 6 and 7). %A Cardoso F %A Paluch-Shimon S %A Schumacher-Wulf E %A Matos L %A Gelmon K %A Aapro MS %A Bajpai J %A Barrios CH %A Bergh J %A Bergsten-Nordström E %A Biganzoli L %A Cardoso MJ %A Carey LA %A Chavez-MacGregor M %A Chidebe R %A Cortés J %A Curigliano G %A Dent RA %A El Saghir NS %A Eniu A %A Fallowfield L %A Francis PA %A Franco Millan SX %A Gilchrist J %A Gligorov J %A Gradishar WJ %A Haidinger R %A Harbeck N %A Hu X %A Kaur R %A Kiely B %A Kim SB %A Koppikar S %A Kuper-Hommel MJJ %A Lecouvet FE %A Mason G %A Mertz SA %A Mueller V %A Myerson C %A Neciosup S %A Offersen BV %A Ohno S %A Pagani O %A Partridge AH %A Penault-Llorca F %A Prat A %A Rugo HS %A Senkus E %A Sledge GW %A Swain SM %A Thomssen C %A Vorobiof DA %A Vuylsteke P %A Wiseman T %A Xu B %A Costa A %A Norton L %A Winer EP %J Breast %V 76 %N 0 %D 2024 Aug 28 %M 38896983 %F 4.254 %R 10.1016/j.breast.2024.103756 %X This manuscript describes the Advanced Breast Cancer (ABC) international consensus guidelines updated at the last two ABC international consensus conferences (ABC 6 in 2021, virtual, and ABC 7 in 2023, in Lisbon, Portugal), organized by the ABC Global Alliance. It provides the main recommendations on how to best manage patients with advanced breast cancer (inoperable locally advanced or metastatic), of all breast cancer subtypes, as well as palliative and supportive care. These guidelines are based on available evidence or on expert opinion when a higher level of evidence is lacking. Each guideline is accompanied by the level of evidence (LoE), grade of recommendation (GoR) and percentage of consensus reached at the consensus conferences. Updated diagnostic and treatment algorithms are also provided. The guidelines represent the best management options for patients living with ABC globally, assuming accessibility to all available therapies. Their adaptation (i.e. resource-stratified guidelines) is often needed in settings where access to care is limited.