%0 Journal Article
%T Intestinal Targeted Nanogel with Broad-Spectrum Autonomous ROS Scavenging Performance for Enhancing the Bioactivity of trans-Resveratrol.
%A Xu J
%A Zhang Y
%A Yao X
%A Wang S
%A Lv K
%A Luo G
%A Wang J
%A Li G
%J Int J Nanomedicine
%V 19
%N 0
%D 2024
%M 38895150
暂无%R 10.2147/IJN.S464849
%X <B>UNASSIGNED: </B>To improve the bioavailability of trans-resveratrol (trans-Res), it is commonly co-delivered with antioxidant bioactives using a complex synthetic intestinal targeted carrier, however, which makes practical application challenging.<BR><B>UNASSIGNED: </B>A nanogel (Ngel), as broad-spectrum autonomous ROS scavenger, was prepared using selenized thiolated sodium alginate (TSA-Se) and crosslinked with calcium lactate (CL) for loading trans-Res to obtain Ngel@Res, which maintained spherical morphology in the upper digestive tract but broke down in the lower digestive tract, resulting in trans-Res release.<BR><B>UNASSIGNED: </B>Under protection of Ngel, trans-Res showed enhanced stability and broad-spectrum ROS scavenging activity. The synergistic mucoadhesion of Ngel prolonged the retention time of trans-Res in the intestine. Ngel and Ngel@Res increased the lifespan of Caenorhabditis elegans to 26.00 ± 2.17 and 26.00 ± 4.27 days by enhancing the activity of antioxidases, upregulating the expression of daf-16, sod-5 and skn-1, while downregulating the expression of daf-2 and age-1.<BR><B>UNASSIGNED: </B>This readily available, intestinal targeted selenized alginate-based nanogel effectively improves the bioactivity of trans-Res.