%0 Journal Article
%T Low-dose decitabine plus venetoclax as post-transplant maintenance for high-risk myeloid malignancies.
%A Parks K
%A Diebold K
%A Salzman D
%A Di Stasi A
%A Al-Kadhimi Z
%A Espinoza-Gutarra M
%A Bhatia R
%A Jamy O
%J EJHaem
%V 5
%N 3
%D 2024 Jun
%M 38895080
暂无%R 10.1002/jha2.915
%X Relapse remains a major cause of treatment failure following allogeneic stem cell transplantation (allo-SCT) for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We retrospectively investigated low-dose decitabine and venetoclax (DEC/VEN) as post-transplant maintenance in 26 older patients with AML and MDS. The cumulative incidence of day 100 gIII-IV acute graft versus host disease (GVHD) and 1-year moderate-severe chronic GVHD was 5% and 26%, respectively. One patient relapsed 14 m after transplant. The 1-year non-relapse mortality and survival were 11% and 84%, respectively. DEC/VEN is a safe and potentially effective strategy to reduce the risk of post-transplant relapse.