%0 Journal Article
%T Systematic review and evidence gap assessment of the clinical, quality of life, and economic burden of alpha-thalassemia.
%A Musallam KM
%A Viprakasit V
%A Lombard L
%A Gilroy K
%A Rane A
%A Vinals L
%A Tam C
%A Rizzo M
%A Coates TD
%J EJHaem
%V 5
%N 3
%D 2024 Jun
%M 38895066
暂无%R 10.1002/jha2.882
%X A recent evidence gaps assessment of the clinical, health-related quality of life, and economic burden associated with α-thalassemia is lacking. We conducted a systematic literature review (SLR) following the methodological and reporting requirements of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Cochrane Handbook for Systematic Reviews, using available literature over the past decade. This SLR identified a considerable evidence gap with regard to understanding the current burden of α-thalassemia as evident from paucity of studies published in the past 10 years. The limited data available still indicate that patients with α-thalassemia experience substantial morbidity and quality of life/economic burden that is generally comparable to patients with β-thalassemia.