%0 Journal Article
%T Effect of apolipoprotein E ε4 and its modification by sociodemographic characteristics on cognitive measures in South Asians from LASI-DAD.
%A Wang YZ
%A Zhao W
%A Moorjani P
%A Gross AL
%A Zhou X
%A Dey AB
%A Lee J
%A Smith JA
%A Kardia SLR
%J Alzheimers Dement
%V 0
%N 0
%D 2024 Jun 18
%M 38889280
%F 16.655
%R 10.1002/alz.14052
%X <B>BACKGROUND: </B>We investigated the effects of apolipoprotein E (APOE) ε4 and its interactions with sociodemographic characteristics on cognitive measures in South Asians from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study of India (LASI-DAD).<BR><B>METHODS: </B>Linear regression was used to assess the association between APOE ε4 and global- and domain-specific cognitive function in 2563 participants (mean age 69.6 ± 7.3 years; 53% female). Effect modification by age, sex, and education were explored using interaction terms and subgroup analyses.<BR><B>RESULTS: </B>APOE ε4 was inversely associated with most cognitive measures (p < 0.05). This association was stronger with advancing age for the Hindi Mental State Examination (HMSE) score (βε4×age = -0.44, p = 0.03), orientation (βε4×age = -0.07, p = 0.01), and language/fluency (βε4×age = -0.07, p = 0.01), as well as in females for memory (βε4×male = 0.17, p = 0.02) and language/fluency (βε4×male = 0.12, p = 0.03).<BR><B>CONCLUSIONS: </B>APOE ε4 is associated with lower cognitive function in South Asians from India, with a more pronounced impact observed in females and older individuals.<BR><B>CONCLUSIONS: </B>APOE ε4 carriers had lower global and domain-specific cognitive performance. Females and older individuals may be more susceptible to ε4 effects. For most cognitive measures, there was no interaction between ε4 and education.