%0 Journal Article
%T Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs.
%A Walther R
%A Park M
%A Ashman N
%A Welch M
%A Carroll JS
%A Spring DR
%J Chem Commun (Camb)
%V 60
%N 55
%D 2024 Jul 4
%M 38888299
%F 6.065
%R 10.1039/d4cc01558d
%X We describe a versatile and tuneable thiol responsive linker system using thiovinylketones, which relies on the conjugate addition-elimination mechanism of Michael acceptors for the traceless release of therapeutics. In a proof-of-principle study, we translate our findings to exhibit potent thiol-cleavable antibiotic prodrugs and antibody-drug conjugates.