%0 Journal Article
%T Systemic Inflammation Differences in Brain-vs. Circulatory-Dead Donors: Impact on Lung Transplant Recipients.
%A Sandiumenge A
%A Bello I
%A Coll-Torres E
%A Gomez-Brey A
%A Franco-Jarava C
%A Miñambres E
%A Pérez-Redondo M
%A Mosteiro F
%A Sánchez-Moreno L
%A Crowley S
%A Fieira E
%A Suberviola B
%A Mazo CA
%A Agustí A
%A Pont T
%J Transpl Int
%V 37
%N 0
%D 2024
%M 38887494
%F 3.842
%R 10.3389/ti.2024.12512
%X Brain death triggers a systemic inflammatory response. Whether systemic inflammation is different in lung donors after brain- (DBD) or circulatory-death (DCD) is unknown, but this may potentially increase the incidence of primary graft dysfunction (PGD) after lung transplantation. We compared the plasma levels of interleukin (IL)-6, IL-8, IL-10 and TNF-α in BDB and DCD and their respective recipients, as well as their relationship with PGD and mortality after LT. A prospective, observational, multicenter, comparative, cohort-nested study that included 40 DBD and 40 DCD lung donors matched and their respective recipients. Relevant clinical information and blood samples were collected before/during lung retrieval in donors and before/during/after (24, 48 and 72 h) LT in recipients. Incidence of PGD and short-term mortality after LT was recorded. Plasma levels of all determined cytokines were numerically higher in DBD than in DCD donors and reached statistical significance for IL-6, IL-10 and IL-8. In recipients with PGD the donor's plasma levels of TNF-α were higher. The post-operative mortality rate was very low and similar in both groups. DBD is associated with higher systemic inflammation than DCD donors, and higher TNF-α plasma levels in donors are associated with a higher incidence of PGD.