%0 Journal Article
%T Radical Prostatectomy Without Prior Biopsy in Selected Patients Evaluated by 18F-Labeled Prostate-Specific Membrane Antigen-Ligand Positron Emission Tomography/Computed Tomography and Multiparameter Magnetic Resonance Imaging: A Single-Center, Prospective, Single-Arm Trial.
%A Niu S
%A Ding X
%A Liu B
%A Ao L
%A Wang H
%A Chen W
%A Xu B
%A Olivero A
%A Liu J
%A Gao J
%A Gao Y
%A Fu W
%A Ma X
%A Li H
%A Wang B
%A Liu Y
%A Zhang X
%J J Urol
%V 0
%N 0
%D 2024 Jun 17
%M 38885328
%F 7.6
%R 10.1097/JU.0000000000004025
%X <B>UNASSIGNED: </B>This study aimed to verify the feasibility and short-term prognosis of prostatectomy without biopsy.<BR><B>UNASSIGNED: </B>Patients with a rising PSA level ranging from 4 to 30 ng/mL were scheduled for multiparametric (mp) MRI and 18F-labeled prostate-specific membrane antigen (PSMA) positron emission tomography (PET). Forty-seven patients (cT2N0M0) with Prostate Imaging Reporting and Data System ≥ 4 and molecular imaging PSMA score ≥ 2 were enrolled. All candidates underwent robot-assisted laparoscopic radical prostatectomy without biopsy. Prostate cancer detection rate, index tumors localization correspondence rate, positive surgical margin, complications, postoperative hospital stay, and PSA level in a 6-week postoperative follow-up visit were collected.<BR><B>UNASSIGNED: </B>All the patients with positive mpMRI and PSMA PET were diagnosed with clinically significant prostate cancer. A total of 80 lesions were verified as cancer by pathology, of which 63 cancer lesions were clinically significant prostate cancer. Fifty-one lesions were simultaneously found by mpMRI and PSMA PET. A total of 23 lesions were invisible on either image, and all lesions were ≤ International Society of Urological Pathology 2 or ≤ 15 mm. Forty-five (95.7%) index tumors found by mpMRI combined with PSMA PET were consistent with pathology. Nine patients reported positive surgical margin.<BR><B>UNASSIGNED: </B>Biopsy-free prostatectomy is safe and feasible for patients with evaluation strictly by mpMRI combined with 18F-PSMA PET/CT.