%0 Journal Article
%T Development of Anti-Inflammatory Drug from Crataeva Nurvala: In Silico and In Vitro Approach.
%A Nithin Krishna K
%A Krishnamoorthy K
%A Veeraraghavan VP
%A Jayaraman S
%J J Pharm Bioallied Sci
%V 16
%N 0
%D 2024 Apr
%M 38882780
暂无%R 10.4103/jpbs.jpbs_594_23
%X <B>UNASSIGNED: </B>Crataeva nurvala, a medicinal plant with potential therapeutic properties, offers a promising avenue for the development of novel anti-inflammatory drugs. This study adopted a combined in silico and in vitro approach to investigate the anti-inflammatory potential of compounds derived from Crataeva nurvala.<BR><B>UNASSIGNED: </B>In the in silico phase, virtual screening and molecular docking analyses were conducted to identify bioactive compounds from Crataeva nurvala that could interact with key inflammatory targets. Subsequently, selected compounds were synthesized and subjected to in vitro experimentation. Cellular models were employed to assess the anti-inflammatory effects of Crataeva nurvala-derived compounds, focusing on the modulation of pro-inflammatory cytokine levels and the underlying signaling pathways.<BR><B>UNASSIGNED: </B>Virtual screening and molecular docking led to the identification of several bioactive compounds with favorable interactions with inflammatory targets. In the in vitro experiments, treatment with Crataeva nurvala-derived compounds resulted in a significant reduction in pro-inflammatory cytokine production. Moreover, the compounds exhibited the ability to modulate inflammatory signaling pathways, further substantiating their anti-inflammatory potential.<BR><B>UNASSIGNED: </B>This study not only contributes to the development of effective anti-inflammatory drugs but also underscores the value of harnessing natural sources such as Crataeva nurvala for therapeutic interventions in inflammatory disorders. The dual-phase strategy presented here provides a robust framework for anti-inflammatory drug discovery and validation.