%0 Journal Article
%T Real-world evidence of sotrovimab effectiveness for preventing severe outcomes in patients with COVID-19: A quality improvement propensity-matched retrospective cohort study of a pan-provincial program in Alberta, Canada.
%A Farmer G
%A Sikdar KC
%A Lo T
%A Conly J
%A Slobodan J
%A Ross J
%A James S
%A Usman H
%A Kemp K
%A Baker K
%A Doucette K
%A Nijssen-Jordan C
%A Saxinger LM
%A Joffe AM
%J Int J Infect Dis
%V 146
%N 0
%D 2024 Jun 14
%M 38880123
%F 12.074
%R 10.1016/j.ijid.2024.107136
%X <B>OBJECTIVE: </B>Post-marketing surveillance of sotrovimab's effect during implementation in the Canadian population is limited.<BR><B>METHODS: </B>The study used a propensity score-matched retrospective cohort design. Follow-up began between the periods of December 15, 2021 and April 30 2022. The study assessed any severe outcome defined as all-cause hospital admission or mortality within 30 days of a confirmed COVID-19-positive test. Covariate-adjusted odds ratios between sotrovimab treatment and the severe outcome was conducted using logistic regression.<BR><B>RESULTS: </B>There were 22,289 individuals meeting the treatment criteria for sotrovimab. There were 1603 treated and 6299 untreated individuals included in the analysis. The outcome occurrence in the study was 5.49% (treated) and 4.21% (untreated), with a median time from diagnosis to treatment of 1.00 days (interquartile range 2.00 days). In the propensity-matched cohort, sotrovimab was not associated with lower odds of a severe outcome (odds ratio 1.20, 95% confidence interval 0.91-1.58), adjusting for confounding variables.<BR><B>CONCLUSIONS: </B>After adjusting for confounding variables, sotrovimab treatment was not associated with lower odds of a severe outcome within 30-days of COVID-19-positive date.